A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression

Inclusion Criteria: * DSM-IV Major Depression or Dysthymia with Atypical Features * Age 18-65 * Physically healthy * HAMD(24) \> 14 Exclusion Criteria: * Prior experience with Duloxetine * History of Psychosis or Bipolar Disorder, Borderline Personality Disorder * Unstable medical disorder; any history of Epilepsy * Currently taking medication that can interact with Duloxetine * Current (past six months) Substance Use Disorder (illicit drugs and/or alcohol) * Serious suicidal ideation judged at least somewhat likely to be acted upon or require hospitalization * Current (past two weeks) use of psychoactive medication (four weeks for Fluoxetine) * Pregnancy * Currently breast feeding * Fecund women failing to use acceptable birth control * Refractory Depression (defined as failure to respond to one or more adequate trials of marketed antidepressants \[i.e., \>=2/3 PDR maximum dose for at least 4 weeks\] during current episode) * Serious suicidal ideation, recent (past six months) suicidal activity, any life-time history of serious suicide attempt (e.g., admitted to ICU, any duration of coma) * Currently taking medication deemed effective