Treatment of Depression Following Multiple Brain Tests

New York State Psychiatric Institute28 enrolled

Overview

The main purpose of this study is to correlate brain testing with treatment outcome.

40 medication-free Depressed Patients will receive a battery of neuropsychologic tests, standard dichotic listening tests, EEG, ERP and an f-MRI while performing a neuropsychologic test, the Simon. Once testing is completed, patients will be treated in an open treatment trial of SSRI. Non-responders will then receive Bupropion followed by Tricyclic Antidepressant if still depressed. While our main purpose is to correlate imaging testing with other measures of brain functioning, we also intend to see whether f-MRI findings demonstrate specific brain areas which differ between responders and non-responders. At the end of SSRI treatment, patients will have a second f-MRI scan to investigate any changes treatment and/or response may have caused.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Major Depression Dysthymia

Interventions

EscitalopramDRUG

8 weeks: up to 40 mg/day

BupropionDRUG

8 weeks: up to 450 mg/day (for patients without history of seizures or risk for developing seizures.

ImipramineDRUG

8 weeks: up to 300mg/day \*if patient does not have contraindication.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * DSM-IV Major Depression or Dysthymia * Age 18-65 * Physically healthy * Normal hearing * Drug-free (two weeks for most antidepressants, four weeks for Fluoxetine) Exclusion Criteria: * Hearing deficit in one or both ears * Body metal (e.g., wire stitches, screws in bones, stainless steel hips) * History of Psychosis or Epilepsy * Current (past six months) Substance Use Disorder (illicit drugs and/or alcohol) * Unstable medical problem * Insufficient English for neuropsychological and dichotic testing * Bipolar I * Need for wash-out from effective treatment in order to participate * Pregnant * High suicide risk * Currently taking (within 2 weeks; 4 weeks for Fluoxetine) antidepressants

Locations (1)

Depression Evaluation Service - New York State Psychiatric Institute

New York, New York, United States

Outcomes

Primary Outcomes

Hamilton Depression Scale (HAM-D)

Time frame: 7 mos.

Secondary Outcomes

Beck Depression Inventory (BDI)

Time frame: 7 mos.

Clinical Global Impression (CGI)

Time frame: 7 mos.

Patient Global Impression (PGI)

Time frame: 7 mos.

Inventory of Depressive Symptoms (IDS)

Time frame: 7 mos.

Edinburgh Handedness Inventory

Time frame: 7 mos.

Chapman Pleasure Scale

Time frame: 7 mos.

Spielberger State/Trait Anxiety Inventory

Time frame: 7 mos.

Data from ClinicalTrials.gov

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