Preoperative Combined Radiochemotherapy for Patients With Rectal Carcinoma

Inclusion Criteria: * Age: 18 - 80 * Biooptical confirmed adenocarcinoma of the lower und middle rectum (lower edge of the tumor located max. 14 cm of the anal verge) * According to MRI tumor extensions into the perirectal fat tissue (cT3) * No former chemotherapy, radiotherapy and/or tumor resection of a rectum carcinoma * WHO performance status 0 - 2 * Adequate bone marrow reserve (leucocytes - not more than 3.000/ml; thrombocytes - not more than 100.000/ml) * Adequate hepatic function (bilirubin - not more than 1.5 x ULN; GOT and GPT - not more than 3.5 x ULN) * Adequate renal function (creatinin - not more than 1.5 mg/dl) * Women of childbearing potential: exclusion of pregnancy (negative urin or serum pregnancy test) * Willingness of women of childbearing potential and accordingly of potent men to use approved contraceptives (for example birth-control pill, loop, condom) during and at least 3 month after closure of the study * Life expectancy of at least 3 month * Signed written Informed Consent before recruitment * Exclusion of distant metastases at the time of recruitment Exclusion Criteria: * Former radio- and/or chemotherapy * Tumor of the upper rectum * Any other kind of malign tumor in the last five years (except adequate treated basal cell carcinoma of the skin, or in situ cervical carcinoma) * Peripheral Neuropathy (NCI CTC - not higher than Grade 1) * General contraindication or hypersensitivity against Oxaliplatin and/or Capecitabine * Any other untreated not malign diseases: Cardiac insufficiency, angina pectoris, hypertension or arrhythmia, hepatic diseases, significant neurological or psychiatric disorders * Florid, serious infection at the time of recruitment * Legally limited capacity or evidence of a neurological or psychiatric disease, the investigator is the opinion it will constrict the patients compliance * Evidence of lacking willingness for cooperation of the patient * Pregnant or breast feeding women