Weight Loss In Obese Subjects Taking Either GW869682 Or Placebo 3 Times Per Day For 12 Weeks

Inclusion criteria: * Have a BMI within range 30.0 to 40.0kg/m2, inclusive. * Females who meet above criteria must be physiologically incapable of becoming pregnant (ie., surgically sterilized, or post-menopausal per protocol definition). Exclusion criteria: * History of eating disorders. * Recent history of weight loss or gain. * Had gastrointestinal surgery for treatment of obesity. * Type 1 or type 2 diabetes mellitus. * Have a positive urine drug screen. * Have liver disease. * Have hepatitis B, hepatitis C, or HIV antibodies. * Have a thyroid disorder that is not under control with medication. * Have any disease (such as heart, liver, blood, nervous system, or kidney disease, or cancer). * Are unable to participate in an exercise program. * Have used weight loss drugs within 3 months before the start of the study. * Are currently using warfarin, digoxin, oral anti-coagulants (other than aspirin and non-steroidal anti-inflammatory drugs), oral or injectable corticosteroids (inhaled \& intranasal corticosteroids are permitted), or antiretroviral medications. * Used of any investigational drug or device during the study or within 30 days prior to 1st dosing of study medication. * High or low blood pressure.