Oral Tolerance in Cow's Milk Allergy in the Infant

Hospices Civils de Lyon50 enrolled

Overview

This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others. Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge. Number and function of regulatory T cells and microflora composition are measured at the same time. Allergic infants are compared to age matched control group.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cow's Milk Allergy

Eligibility

Sex: ALLMin age: 1 MonthMax age: 15 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day Exclusion Criteria: immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.

Locations (1)

Alain Lachaux

Lyon, France

RECRUITING

Central Contacts

Florence VILLARD-TRUC, MD

CONTACT

33 472 110 390 fvillardtruc@hotmail.com

Dominique KAISERLIAN, PhD

CONTACT

kaiserlian@cervi-lyon.inserm.fr

Data from ClinicalTrials.gov

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