Influence of G-CSF and EPO on Associative Learning and Motor Skills

University Hospital Muenster180 enrolled

Overview

In the study we want to prove whether the subcutaneous application of granulocyte-stimulating factor (G-CSF) and erythropoetin (EPO) influence associative learning and/or motor skills of patients, who suffer from chronic stroke or amyotrophic lateral sclerosis. The study hypothesis is that G-CSF and EPO improve associative learning and/or motor skills.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

180

Conditions

Chronic Stroke Amyotrophic Lateral Sclerosis

Interventions

granulocyte - colony stimulating factor (G-CSF)DRUG

erythropoetin (EPO)DRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of chronic stroke or amyotrophic lateral sclerosis Exclusion Criteria: * leucocytes \> 10000/µl * hematocrit \> 48% * thrombocytes \< 150000/µl * severe rheumatoid arthritis * severe infection * severe liver or renal failure * severe arterial hypertension * recurrent thromboembolic events * severe coronary heart disease * myocardial infarction * malignant tumor * leukemia * peripheral arterial occlusion disease

Locations (1)

Department of neurology, University Hospital of Muenster

Münster, North Rhine-Westphalia, Germany

Outcomes

Primary Outcomes

Learning success in a word learning model

Response time in motor function tests

Secondary Outcomes

Response time in a word learning model

Total time and number of keystrokes in motor function tests

Data from ClinicalTrials.gov

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