The purpose of this study is to elucidate whether the individualized medicine based on NAT2 gene polymorphism could improve the safety, efficacy and economical benefits of multi-drug therapy for the pulmonary tuberculosis with isoniazid.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
172
Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
Habikino, Osaka, Japan
Osaka Hospital, Anti-Tuberculosis Association, Osaka Branch
Neyagawa, Osaka, Japan
National Hospital Organization Kinki-chuo Chest Medical Center
Sakai, Osaka, Japan
National Hospital Organization Toneyama
Toyonaka, Osaka, Japan
The incidences of unfavorable events in two different treatment regimens based on the NAT2 gene polymorphism
1\) the incidences of drug-induced liver injury associated with INH that occurred within 8 weeks of the treatments, and 2) the incidence of early treatment failure as indicated by a persistent positive culture or no improvement in chest radiographs at the 8th week
Other adversed events during the 8 weeks of the intensive phase of the anti-tuberculosis therapy
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