A Study of Pain Relief in Osteoarthritis

Inclusion Criteria: * Males and females ages 21 to 80 * If female, must be of non-child bearing potential or practicing birth control * Has osteoarthritis of the hip or knee * Requires therapeutic doses of medication for osteoarthritis pain * Has sufficient pain to justify the use of around-the-clock opioids Exclusion Criteria: * Is associated with any currently ongoing research study, or has previously participated in a Vicodin CR study * Is allergic to or has had a serious reaction to hydrocodone, other opioids, or acetaminophen * Cannot discontinue pain medications, even for the short time prior to the study start * Has any clinically significant illness or recent injury, or has any significant laboratory abnormality, or has recently had major surgery * Has a history of gastric bypass surgery or preexisting severe gastrointestinal narrowing, or history of diseases that may narrow the gastrointestinal tract * Has a history of malnutrition or starvation * Has a history of drug (licit or illicit) or alcohol abuse or addiction, or consumes more than 4 alcoholic drinks per day * Has a history of a major depressive episode within the past 2 years, or requires treatment with certain drugs for depression, or has a history of major psychiatric disorder * Pregnant or breastfeeding females * Is incapacitated, bedridden or confined to a wheelchair * Has initiated any new therapy or medication for OA within 1 month of screening * Has had surgery, certain types of procedures, or received certain medications for osteoarthritis within a specified time frame * Has other conditions that may cause pain, such as rheumatoid arthritis or gout