Left Main Coronary Artery Stenosis and Angioplasty With Taxus Stent

Inclusion Criteria: * The patient must be \> or = 18 years of age * Patient must provide written informed consent prior to the procedure using a form that is approved by the local Ethics Committee * Aspirin + Clopidogrel \> or = 12 hours before percutaneous coronary intervention (PCI) * Documented evidence of ischemic heart disease (clinical,biological or ECG) with unprotected left main coronary artery stenosis \> or = 50% associated to other coronary lesions or not responsible of stable or unstable coronary syndrome above 48 hours * The target reference vessel diameter must be \> or = 2.5 mm * Unprotected left main coronary artery disease eligible by coronary stenting Exclusion Criteria: * Restenosis lesion in left main coronary artery * Known allergies to the following: aspirin, clopidogrel,ticlopidine,contrast agent or drug similar to paclitaxel * Acute coronary syndrome \< 48 hours * Impaired renal function (creatinine \> 180 ùmol/l) at the time of treatment * Life expectancy less than 36 months * Female of childbearing potential without reliable birth control * Currently participating in an investigational drug or device study that has not completed the primary endpoint or that clinically interferes with the study endpoints