Therapeutic Effect of Immunoadsorption for Patients With Lipoprotein Glomerulopathy

Nanjing University School of Medicine20 enrolled

Overview

The purpose of this study is to assess the efficacy and safety of immunoadsorption in the treatment of lipoprotein glomerulopathy.

Lipoprotein glomerulopathy is characterized by nephritic syndrome glomerular protein thrombi and lipid abnormalities, particularly with an elevated level of plasma apoprotein E (apoE).There are no efficiency way to treat lipoprotein glomerulopathy. We firstly successfully treat 2 patients by protein A immunoadsorption with remarkable decreased urine protein and reduction of lipoprotein thrombi on repeated renal biopsy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Treatment

Interventions

immunoadsorptionPROCEDURE

immunoadsorption

Eligibility

Sex: ALLMin age: 15 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. A new diagnosis of lipoprotein glomerulopathy proved by histology and serology 2. Age 15\~60 years, sex free Exclusion Criteria: 1. Serum creatinine \> 500 umol/l 2. Severe viral infection(HBV, HCV, CMV) within 3 months of first randomization or known HIV infection 3. Congenital or acquired immunodeficiency 4. Patients with severe infection or central nervous system symptoms 5. Immediately life-threatening organ manifestations (e.g. lung haemorrhage or massive gastro-intestinal bleeding, heart failure due to pericarditis or myocarditis, liver dysfunction measured on at least 2 separate occasion)

Locations (1)

Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

To assess the efficacy of immunoadsorption in the treatment of lipoprotein glomerulopathy.

Time frame: 3 months

Secondary Outcomes

To assess the safety of immunoadsorption in the treatment of lipoprotein glomerulopathy.

Time frame: 3 months

Data from ClinicalTrials.gov

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