The study evaluates the additional use of radioimmunotherapy with a 90-Yttrium labeled monoclonal antibody targeting lymphoma cells in two dose reduced conditioning regimens for allogeneic hematopoietic cell transplantation from human leukocyte antigen (HLA)-identical donors. Radioimmunotherapy should allow an increased anti-lymphoma effect of the conditioning while the allogeneic grafts may confer potent graft versus lymphoma effects and rescue from potential hematopoietic side effects of the radioimmunotherapy. The study evaluates the feasibility and toxicity of such approach and will also analyze disease response and survival of the patients treated.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Medical Center Charite Benjamin Franklin
Berlin, Germany
University of Dresden Medical Center
Dresden, Germany
Center for Marrow Transplantation, University of Essen
Essen, Germany
Medical Center University of Goettingen
Göttingen, Germany
Medical Center University of Hannover
Hanover, Germany
Medical Center University of Leipzig
Leipzig, Germany
Medical Center University of Muenster
Münster, Germany
South West German Cancer Center, University of Tuebingen Medical Center
Tübingen, Germany
Medical Center University of Ulm
Ulm, Germany
Stiftung Deutsche Klinik für Diagnostik GmbH
Wiesbaden, Germany
...and 1 more locations
treatment related toxicity
engraftment
disease response
relapse rate
disease free survival
overall survival
graft versus host disease (GVHD)
immunoreconstitution
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