Effectiveness of Plasma Transfusions in Critical Care Patients

Inclusion Criteria: * ICU Admission * INR \> 1.2 * Require FFP for active bleeding and/or prior to an invasive procedure * Are able to provide consent or proxy consent Exclusion Criteria: * Congenital or acquired coagulation factor deficiency * Platelet count \< 50 x 109 /L and have NOT received subsequent platelet transfusion * Consumptive coagulopathy (bleeding ≥ 3 sites and ↓ plts, ↓ fib, ↑ d dimer) * Uncontrolled bleeding (6 or more units of blood in the last 6 hours) * Receiving therapeutic doses of heparin/heparinoid (must be off for at least 6 hours) * Have received clotting factor concentrates in the previous 24 hours * Are expected to require surgery in the next 48 hours * Survival expected to be less than 48 hours * Currently enrolled in another study with a similar outcome * Previous enrollment in this study