A Study of P38 Inhibitor (4) Monotherapy in Patients With Active Rheumatoid Arthritis

Inclusion Criteria: * adult patients \>18 years of age, with active RA; * receiving treatment for RA on an outpatient basis; * females of child-bearing potential, or nonsterilized males with partners of child-bearing potential, must use reliable contraception during, and for 4 weeks after, the study. Exclusion Criteria: * major surgery within 8 weeks prior to screening; * rheumatic autoimmune disease or inflammatory joint disease other than RA; * treatment with methotrexate within 8 weeks of baseline; * concurrent use of DMARDs, including anti-TNF or other biologic therapy for RA.