A 12-Week Safety and Pharmacodynamic Study of AT1001 (Migalastat Hydrochloride) in Female Participants With Fabry Disease

Inclusion Criteria: * Females between 18 and 65 years of age (inclusive) * Heterozygous for Fabry disease * Had a confirmed diagnosis of Fabry disease with a documented missense gene mutation (individual or familial) * Had enhanceable enzyme activity based on in vitro tests * Were naïve to enzyme replacement therapy (ERT) and other therapies, except for palliative therapies for the signs and symptoms of Fabry disease, or stopped ERT for at least 18 weeks * Had end organ dysfunction, even minimal, demonstrated by abnormal electrocardiogram (ECG) or evidence of left ventricular hypertrophy documented by echocardiogram or by cardiac biopsy; or renal insufficiency documented by common clinical assessments such as creatinine and glomerular filtration rate or by renal biopsy; or brain tissue dysfunction as documented by evidence of stroke (clinically or imaging); or peripheral nervous tissue dysfunction documented by complaints of intolerance to heat or cold, decreased vibratory sense and proprioception, decreased ability to perspire, or acroparesthesia. * Were willing to undergo 2 renal and 3 skin biopsies * Agreed to be sexually abstinent or practice an effective method of contraception when engaging in sexual activity during the course of the study and for a period of 30 days following their completion of the study for women of childbearing potential. * Were willing and able to provide written informed consent Exclusion Criteria: * Pregnant or lactating * History of organ transplant * History of significant disease other than Fabry disease (for example, end-stage renal disease; Class III or IV heart disease \[per the New York Heart Association classification\]; current diagnosis of cancer, except for basal cell carcinoma of the skin; diabetes \[unless hemoglobin A1c ≤8\]; or neurological disease that would have impaired the participant's ability to participate in the study) * Serum creatinine \>176 micromoles/liter on Day -2 * Screening 12-lead ECG demonstrating corrected QT interval \>450 milliseconds * Pacemaker or other contraindication for magnetic resonance imaging scanning * Taking a medication prohibited by the protocol: Fabrazyme® (agalsidase beta), Replagal™ (agalsidase alfa), Glyset® (miglitol), Zavesca® (miglustat), or any experimental therapy for any indication * Participated in a previous clinical trial in the last 30 days * Any other condition which, in the opinion of the investigator would jeopardize the safety of the participant or impact the validity of the study results.