Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status

Inclusion Criteria: * Man and non-pregnant women aged between 15 and 50. * P.falciparum mono-infection of at least 1,000 parasites/µl. * Body temperature ≥ 37.5°C at the moment of enrolment or history of fever in the preceding 48 hrs. * Consent from patient obtained. Exclusion Criteria: * Pregnancy. * Severe P. falciparum malaria . * Documented intake of SP or Coartem two weeks or less prior recruitment. * Other cause(s) of fever. * Evidence of underlying chronic diseases (cardiac, renal, hepatic, malnutrition). * History of allergy to study drug, or known allergy to other Sulphur drugs such as co-trimoxazol.