Identification and Treatment of the Liability to Develop Schizophrenia

Inclusion Criteria: * Having at least one first-degree biological relative with schizophrenia and their age is between 19 and 59. * Desire to participate in a medication trial. * Is able to provide informed consent. * Having moderate levels of negative symptoms, defined as 6 items rated 3 or higher on the Scale for the Assessment of Negative Symptoms (SANS). * Scoring two or more standard deviations below normal in at least one of three cognitive domains: vigilance/working memory, long-term verbal memory, and executive functions. * Scoring at least one standard deviation below normal in a second cognitive domain. Exclusion Criteria: * IQ less than 80. * Formal education less than 10 years. * History of psychotic disorders. * History of treatment with an antipsychotic medication. * A substance abuse diagnosis within 6 months of diagnosis. * A head injury with documented loss of consciousness exceeding 5 minutes (or subsequent cognitive deficits). * A history of neurologic disease or damage. * A medical condition with significant cognitive sequelae. * A history of electroconvulsive treatment.