This purpose of this study is to determine whether phototherapy can be used to safely and effectively treat H pylori.
H pylori causes almost all peptic ulcers and many gastric cancers and is widely prevalent worldwide. Treatment by multiple antibiotics and proton pump inhibitors is effective but are compromised today by significant non compliance due to side effects and duration of required treatment. Also, the increase in antibiotic resistance coupled with the decreased availability of new antibiotics project a significant population of patients who will not be treatable with antibiotics. A special, visible-light based phototherapy system has been demonstrated to significantly decrease the viability of H pylori in vitro and in a brief clinical experiment. This study will evaluate the safety and short term efficacy in up to 60 patients of the phototherapy system to treat H pylori.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Beth Israel Deaconness Medical Center
Boston, Massachusetts, United States
RECRUITINGUMass Memorial Medical Center
Worcester, Massachusetts, United States
RECRUITINGAbbott Northwestern Hospital
Minneapolis, Minnesota, United States
NOT_YET_RECRUITINGNegative urease breath test at five weeks post procedure
Procedural Side Effects
Negative urease breath test at 5 days post procedure
Reduction in acute post treatment bacterial population with respect to pretreatment samples
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.