Phase I Study of BMS-188667 (CTLA4Ig) in Patients With Psoriasis Vulgaris

Inclusion Criteria: * Men or women who received adequate counseling and were judged reliabel in their use of contraceptive measures. * Diagnosis and documentation of stable psoriasis vulgaris of at least 6 months duration. * Psoriasis vulgaris total body surface area involvement between 10% and 49% (Overall Disease Severity Score \[ODSS\]of 4-7 inclusive). * Failure of toxicity or inefficacy of at least one standard antipsoriatic therapy including topical treatment, etretinate, phototherapy, or methotrexate. Exclusion Criteria: * Treatment with: a) Retinoids within 2 years, b) cyclosporin A, systemic corticosteroids, methotrexate, or an investigational agent within 16 weeks, c) any phototherapy or photochemotherapy within 4 weeks d) any topical psoriasis treatment other than emollients within 2 weeks prior to enrollment. * No clinical response to a prior adequate therapeutic trial of cyclosporin A * Prolonged exposure to the sun within 4 weeks prior to the first dose. * Guttate, erythrodermic, or pustular psoriasis. * Spontaneously improving or rapidly deteriorating psoriasis vulgaris.