Safety and Efficacy Study of Investigational Pneumococcal Vaccine in Elderly Population

Inclusion criteria * Subjects who the investigator believes will comply with the requirements of the protocol * A male or female ≥ 65 years at the time of the first vaccination. * Written informed consent obtained from the subject. * Free of obvious health problems as established by medical history and clinical examination before entering into the study. Exclusion criteria * Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period or participation to another pharmaceutical/vaccine study. * Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the first vaccine dose. * Use of any anticoagulants. * Planned administration/ administration of a vaccine not foreseen by the study protocol within 2 weeks of the first dose of vaccines. * Previous vaccination against Streptococcus pneumoniae. * Bacterial pneumonia within 3 years prior to 1st vaccination. * Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection. * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine. * Current serious neurologic or mental disorders. * Currently smoking \> 25 cigarettes per day. * Inflammatory processes such as known chronic active infections * All malignancies (excluding non-melanic skin cancer) and lymphoproliferative disorders diagnosed or treated actively during the past 5 years. * History of administration of an experimental vaccine containing MPL or QS21. * Acute disease at the time of enrolment. * Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests, at the discretion of the investigator. * History of chronic alcohol consumption and/or intravenous drug abuse.