Changes in Iron Markers Following Iron Loading in Hemodialysis Patients

Papageorgiou General Hospital160 enrolled

Overview

The purpose of this study is to describe alterations of serum ferritin, transferrin saturation, soluble transferrin receptor, % hypochromic erythrocytes, % reticulocytes, reticulocyte hemoglobin content after iron loading in hemodialysis patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

160

Conditions

Anemia in Chronic Renal Disease

Interventions

iron sucroseDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * hemodialysis for three months minimum * stable epoetin dose for two months minimum * serum ferritin concentration \< 1000 ng/ml * transferrin saturation \< 50% * parathormone concentration \< 800 pg/ml Exclusion Criteria: * hemoglobin concentration \> 13g/dl * serum ferritin concentration \< 20 ng/ml * vitamin B12 and/or folic deficiency * other hematologic disease than anemia * cancer * hypothyroidism * infectious disease

Locations (1)

Papageorgiou General Hospital

Thessaloniki, Greece

Outcomes

Primary Outcomes

Ferritin alterations after iron loading at six and twelve weeks from the beginning of iron loading.

Secondary Outcomes

All iron indices' alterations during twelve weeks from the beginning of iron loading.

Data from ClinicalTrials.gov

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