Randomized Study Comparing Pre- and Postoperative vs. Conventional Adjuvant Treatment in Receptor-negative Patients

Inclusion Criteria: * Patients with bioptically verified breast cancer * Estrogen receptor-negative status * Age: \< 70 years * WHO Performance Status \< 2 * Laboratory parameters 1. hematopoiesis: \> 3500/mm3 leukocytes, \> 100,000/mm3 thrombocytes 2. renal function: creatinin \< 1.5mg% 3. hepatic function: GOT max. 2.5 x UNL 4. bilirubin: \< 2.0 mg % 5. metabolic parameters: Na, Ca, K in normal range * \</= 4 weeks interval since surgery * Informed consent Exclusion Criteria: * Patients with locally inoperable cancer, M1 * Other preoperative tumor-specific radiotherapy, chemotherapy or endocrine treatment * Pregnancy or lactation * General contraindication against cytostatic treatment * T4 cancer; inflammatory disease, simultaneous or sequential bilateral breast cancer * Lacking compliance or understanding of disease * Serious concomitant disease * Second carcinoma or status post second carcinoma (except for treated squamous cell carcinoma of the skin or cervical carcinoma in situ)