Study of Sildenafil in Patient With Heart Failure.

Massachusetts General Hospital40 enrolled

Overview

The purpose of this study is to determine if sildenafil (Viagra) improves exercise tolerance.

Patients will undergo an exercise stress test. One dose of Sildenafil will then be given, followed by a one hour rest period. A repeat exercise stress test will then be repeated.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Congestive Heart Failure

Interventions

sildenafilDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Age 18 - 75 Ejection fraction \<35% Heart failure limited by fatigue and shortness of breath - Exclusion Criteria: Inability to exercise. Patients with shortness of breath while resting. Patient requiring intravenous medication. Patients taking the following medications: nitroglycerine pill/patch/paste, isordil and Imdur \-

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Patients will have exercise capacity measured by an exercise stress test before and after one dose of sildenafil.

Data from ClinicalTrials.gov

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