The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).
The purpose of this study is to determine the effect of chronic intermittent nocturnal hypoxia on selected hepatic drug-metabolizing enzyme systems in children with OSAS. The specific aims are to evaluate the activities of cytochrome P450 (CYP)1A2, N-acetyltransferase-2 (NAT-2), xanthine oxidase (XO)and CYP2D6 in children with OSAS and to determine the effect of OSAS treatment on the activities of these enzyme systems.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
69
0.5 mg/kg (maximum 30 mg)
Administered as 4 ounces of Coca-Cola
University of Louisville
Louisville, Kentucky, United States
Virginia Commonwealth University
Richmond, Virginia, United States
Caffeine urinary molar ratio
Time frame: Pre and post T&A
Dextromethorphan urinary molar ratio
Time frame: Pre and post T&A
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.