Renoprotective Effect of Nisoldipine and Lisinopril in Type 1 Diabetic Nephropathy

Steno Diabetes Center Copenhagen52 enrolled

Overview

The aim of the study was to compare the renoprotective effect of a long acting calcium antagonist (nisoldipine) with an angiotensin converting enzyme inhibitor (lisinopril)in type 1 diabetic patients with diabetic kidney disease. In total, 51 patients were randomised to treatment with one of these drugs for 4 years. Changes in kidney function, blood pressure and urinary excretion of albumin were measured every 6 months

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Diabetic Nephropathy

Interventions

nisoldipineDRUG

lisinoprilDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diabetic nephropathy, type 1 diabetes, hypertension Exclusion Criteria: * child bearing potential, non-diabetic kidney disease, malignancy

Locations (1)

Steno Diabetes Center

Gentofte Municipality, Denmark

Outcomes

Primary Outcomes

change in glomerular filtration rate from study start to study end

Secondary Outcomes

blood pressure response

change in urinary albumin excretion rate

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.