Hydroxychloroquine in Cystic Fibrosis

Inclusion Criteria: 1. Male or female between 16 years and 65 years of age. 2. Confirmed diagnosis of CF based on the following criteria: i. positive sweat chloride 60 mEq/liter (by pilocarpine iontophoresis) and/or ii. a genotype with two identifiable mutations consistent with CF, and iii. accompanied by one or more clinical features consistent with the CF phenotype 3. FEV1 50% predicted value (subjects 16- \<18 years of age) or 40% predicted value (subjects 18 years of age) 4. Clinically stable with no evidence of acute upper or lower respiratory tract infection or current pulmonary exacerbation within the 14 days prior to Visit 1 (Day 0) 5. Ability to reproducibly perform spirometry and peak flow measurements 6. Ability to understand and sign a written informed consent or assent and comply with the requirements of the study Exclusion Criteria: 1. Use of an investigational agent within the 4-week period prior to Visit 1 2. Chronic daily use of ibuprofen or other NSAIDs, or systemic corticosteroids, or any oral diabetic or hypoglycemic agent within the 4 weeks prior to Visit 1 or acute usage within 72 hours prior to Visit 1 3. History of hypersensitivity to beta-agonists 4. History of hypersensitivity to hydroxychloroquine or chloroquine 5. Oxygen saturation \< 92% on room air at Visit 1 6. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study 7. History of hemoptysis 30 cc per episode during the 30 days prior to Visit 1 8. Significant history of hepatic, cardiovascular, renal, neurological, hematologic, or peptic ulcer disease