Thalamic Deep Brain Stimulation for Tourette Syndrome

Phase 2CompletedNCT00311909

University Hospitals Cleveland Medical Center5 enrolled

Overview

The purpose of this study is to determine whether deep brain stimulation is effective at reducing tic frequency and severity in adults with Tourette syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Tourette Syndrome

Interventions

Thalamic deep brain stimulationDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 or older * Diagnosis of Tourette Syndrome by DSM-IV * Tic frequency at least one per minute at screening * prior failure of at least two dopamine receptor or presynaptic blockers * negative impact on quality of life Exclusion Criteria: * significant structural brain lesion (on imaging studies) * significant dementia * severe head trauma preceding onset of tics * use of dopamine receptor blockers prior to recognition of tics * prior implanted electrical device * electroconvulsive therapy (ECT) within 24 months * suicide attempt within 12 months * significant sociopathic personality * current or planned pregnancy

Locations (1)

University Hospitals of Cleveland

Cleveland, Ohio, United States

Outcomes

Primary Outcomes

modified Rush Video Rating Scale (mRVRS)

Secondary Outcomes

tic counts (on video recording)

Yale Global Tourette Severity Scale (YGTSS)

Tourette Syndrome Symptom List (TSSL)

Quality of Life Visual Analog Scale (VAS)

SF-36

Neuropsychological battery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.