NCT00312338 - Topical Treatment of Bacterial Conjunctivitis and Its Effect on Microbial Flora | Crick

Overview

Topical Treatment of Bacterial Conjunctivitis and its Effect on Microbial Flora

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

SINGLE

Enrollment

137

Conditions

Bacterial Conjunctivitis

Interventions

VIGAMOXDRUG

1 drop of VIGAMOX® ophthalmic solution 0.5% in both eyes TID for 7 days

Eligibility

Sex: ALLMin age: 1 YearMax age: 13 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients from 1 to 13 years of age that have diagnosis of bacterial conjunctivitis in either or both eyes (for \< 3 days duration) based on clinical observation; matched healthy controls Exclusion Criteria: * Cannot have had bacterial conjunctivitis symptoms as reported by parent for \> 2 days

Locations (1)

Multiple Locations

Fort Worth, Texas, United States

Outcomes

Primary Outcomes

Susceptability Changes in Streptococcus Pneumoniae Distal to the Site of Instillation

Susceptibility change refers to a change in vulnerability of a specified bacterial strain to antibiotic treatment. Susceptibility was assessed by broth microdilution methods recommended by the Clinical and Laboratory Standards Institute (CLSI). 0% = zero isolates were resistant to antibiotic 100% = all isolates were resistant to antibiotic

Time frame: Day 0 and Day 42

Susceptability Changes in Staphylococcus Aureus Distal to the Site of Instillation

Susceptibility change refers to a change in vulnerability of a specified bacterial strain to antibiotic treatment. Susceptibility was assessed by broth microdilution methods recommended by the Clinical and Laboratory Standards Institute (CLSI). 0% = zero isolates were resistant to antibiotic 100% = all isolates were resistant to antibiotic

Time frame: Day 0, Day 42

Susceptability Changes in Haemophilus Influenzae Distal to the Site of Instillation

Susceptibility change refers to a change in vulnerability of a specified bacterial strain to antibiotic treatment. Susceptibility was assessed by broth microdilution methods recommended by the Clinical and Laboratory Standards Institute (CLSI). 0% = zero isolates were resistant to antibiotic 100% = all isolates were resistant to antibiotic

Time frame: Day 0, Day 42