Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

Erling Bjerregaard Pedersen50 enrolled

Overview

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Renal Insufficiency, Chronic Hypertension

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with chronic renal insufficiency, aged between 18 and 65, both men and women * Creatinine clearance between 30-59 ml/min * Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg. * Healthy volunteers, aged between 18 and 65, both men and women Exclusion Criteria: * Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs * Cancer * Alcohol abuse * Medicine abuse * Pregnancy

Locations (1)

Department of Medicine, Holstebro Hospital

Holstebro, Ringkjoebing, Denmark

Data from ClinicalTrials.gov

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