The objective of this study is to determine if concentrations of amiodarone in fat tissue increases constantly over time during chronic treatment with this drug, and if blood concentrations reflect accurately the concentrations in fat tissue or not. This is because excessive concentrations of this drug in tissues can produce adverse effects.
Amiodarone is very effective to treat cardiac arrhythmias but its use is limited by its toxicity, specially in chronic treatment. Accumulation of the drug in tissues is very probably the cause of the majority of amiodarone delayed adverse effects. However, this has not been proved because obtaining tissue samples is usually difficult and aggressive. The investigators study, in patients following chronic treatment with amiodarone, if needle aspiration can provide samples of fat tissue useful to accurately determine amiodarone concentrations, how those concentrations in fat tissue correlate with cumulated dose, and how concentrations in fat tissue correlate with concentrations in blood, which is easier to obtain. The investigators expect this knowledge will help to understand how amiodarone develops its adverse effects and possibly lead to new ways of monitoring treatment with this drug, or to adapt doses in chronic administration.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
30
Small fat tissue sampling performed by needle aspiration.
Hopital Lariboisiere, Internal Medicine "A" and Cardiology Services
Paris, France
Relationship Between Amiodarone Concentration in Fat Tissue and Cumulated Dose.
Correlation between amiodarone concentration in fat tissue (mean from several sampling points) and cumulated dose.
Time frame: One single measure
Relationship Between Amiodarone Concentrations in Fat Tissue and in Plasma.
Correlation between amiodarone concentrations in fat tissue (mean of 2 samples) and simultaneous concentration in plasma.
Time frame: One single measure, taken just before daily administration
Relationship Between Amiodarone Concentrations in Fat Tissue and Developing Adverse Effects.
Relationship between amiodarone concentrations in fat tissue (mean of two different samplings and developping adverse effects.
Time frame: Cumulated time on amiodarone (varies in each patient)
Pain and Complications (if Any) Caused by Fat Tissue Needle Aspirations
Number of patients having complications (if any) caused by fat tissue needle aspirations
Time frame: 24 hours after needle aspiration
Presence of Any Adverse Effect Attributable to Amiodarone.
Number of patients developing adverse effects by amiodarone leading to withdrawal or specific treatment (i.e. thyroid hormone treatment)
Time frame: Cumulated time on amiodarone (varies in each patient)
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