High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients

Inclusion Criteria: * Patients with a documented history of hypertension defined as: SBP \> or = 140 mmHg or DBP \> or = 90 mmHg if hypertension untreated or patients currently treated for hypertension. * Documented CAD or diabetes or impaired glucose tolerance * Sinus rhythm Principal Exclusion Criteria: * Previous intolerance or allergic reaction to an ACE inhibitor, an ARB or dihydropyridine calcium channel blocker * History of angioedema or cough related to previous ACE inhibitor use. * Systolic blood pressure \> 180 mmHg or diastolic blood pressure \> 110 mmHg in untreated patients * Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 100 mmHg in patients currently treated by an ACE inhibitor or an ARB * Creatinine clearance \< 30 ml/min * Significant liver dysfunction * Current serum potassium \> or = 5 mmol/L or a history of marked ACE inhibitor or ARB induced hyperkalemia resulting in either a serum potassium \> or = 5.5 mmol/L or a life-threatening adverse event. * History of HF or known LVEF \< or = 45% * Bilateral renal artery stenosis (or unilateral if only one kidney) * Unstable angina, myocardial infarction or coronary revascularization within the last 3 months. * Connective tissue disease or chronic inflammatory condition * Active malignancy * Active infection in the last 2 weeks * Inability or any contraindication to perform an exercise test.