The Effect of Exercise on Blood Glucose Levels in Patients With Type 1 Diabetes: A Comparison of 3 Long-acting Insulins

Novo Nordisk A/S51 enrolled

Overview

This trial is conducted in Europe. The aim of this research is to assess the impact of three basal (long-acting) insulin treatments on blood glucose levels in people with type 1 diabetes when performing physical exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Diabetes Diabetes Mellitus, Type 1

Interventions

insulin detemirDRUG

insulin glargineDRUG

insulin NPHDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Type 1 Diabetes * Current basal-bolus insulin therapy * HbA1c \< 10% * BMI \< 32 kg/m2 Exclusion Criteria: * Proliferative Retinopathy / Maculopathy * Recurrent major hypoglycaemias * Impaired hepatic or renal function * Cardiac Problems * Uncontrolled hypertension

Locations (2)

Unnamed facility

Neuss, Germany

Unnamed facility

Newcastle upon Tyne, United Kingdom

Outcomes

Primary Outcomes

The difference between plasma glucose concentrations immediately pre-exercise and the minimum plasma glucose concentrations (nadir) in the period 0-150 min following exercise

Time frame: following 4 weeks of treatment

Secondary Outcomes

Plasma glucose pre-exercise & post-exercise

Hypoglycaemia episodes (major and minor episodes) during exercise, afterwards & from end of study until 07:30 the following morning

Plasma glucose profile post-exercise

Incidence of adverse events during the trial

Data from ClinicalTrials.gov

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