Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis.

Inclusion Criteria: * Informed consent obtained from the subject. * Aged 18 years or above at screening. * In good general health * Subject available for the study duration * For female subjects (of child bearing potential) a negative pregnancy tests at Screening and Day 0. Exclusion Criteria: * A history of vaccination against or infection with JE. * Known or suspected immunodeficiency, use of immunosuppressive or antineoplastic drugs. * History of thymoma, thymic surgery (removal) or myasthenia gravis. * Clinically significant abnormalities on laboratory assessment * Anaphylaxis or other serious adverse reactions characterised by urticaria or angioedema to foods, Hymenoptera (bee family) stings, or drugs including vaccines). * Transfusion of blood or treatment with any blood product, including intramuscular or intravenous serum globulin within six months of the Screening Visit or up to Day 30. * Administration of another vaccine or antiviral within 30 days preceding the Screening visit or up to Day 30. * Physical examination indicating any clinically significant medical condition. * Oral temperature \>38°C (100.4°F) or acute illness within 3 days prior to inoculation. * Intention to travel out of the area for an extended period that may affect the subjects ability to attend clinic visits prior to the study visit up to Day 30. * Seropositive to hepatitis C virus (HCV) or HIV or positive for Hepatitis B Surface Antigen. * Lactation or intended pregnancy in female subjects. * Excessive alcohol consumption, drug abuse, significant psychiatric illness. * A known or suspected physiological or structural condition that compromises the integrity of the blood-brain barrier (e.g. cerebrovascular disease, multiple sclerosis, trauma, infection, inflammation of the brain or meninges). * Participation in another clinical study within 30 days of the screening visit for this study. * Employee of the study site, Sponsor or Clinical Research Organization (CRO) involved with the management of the study. * Any other reasons, which in the investigator's opinion, makes the subject unsuitable to participate in the study.