Study Evaluating PD-0299685 for the Treatment of Vasomotor Symptoms (Hot Flashes / Flushes) Associated With Menopause

Inclusion Criteria: * Postmenopausal as defined by 6 months of spontaneous amenorrhea with serum FSH levels \>40mlU/ml and estradiol \< than = 25 pg/mL or 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy and FSH levels \> 40 mlU/ml and estradiol \< than = 25 pg/mL * Women reporting at least 50 moderate to severe vasomotor symptoms per week, recorded for seven consecutive days * Aged 40 to 70 years Exclusion Criteria: * No estrogen monotherapy or estrogen/progesterone containing drug products within applicable wash out period prior to screening * Use of SERMs, clonidine within 4 weeks of screening * Use of CNS active medication within 1 week of screening * Use of medications (SSRI; SNRI), herbal or dietary supplements, including black cohosh, soy, phytoestrogens or over the counter agent known to possibly be effective for the treatment of vasomotor symptoms, within 4 weeks of screening * Participation in clinical trial within 30 days * Significant medical or psychiatric illness within past 12 months