Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology

Children's Mercy Hospital Kansas City63 enrolled

Overview

This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC), or Hypoxic Respiratory Failure (HRF).

This genetic predisposition study does not involve investigational drugs, devices, or treatments. Our broad goal is to identify genomic factors, which contribute to the development or exacerbation of common and critical illnesses that affect preterm and near-term infants. We seek to accomplish this goal in the following ways: * First: to test candidate gene DNA variations and link already identified single nucleotide polymorphisms (SNPs) producing functional alterations to the risk of clinically important disorders. * Second: to utilize a whole-genomic approach to identify SNPs not previously linked to the risk of development or progression of neonatal disorders.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung Disease Brain Injury Necrotizing Enterocolitis Respiratory Failure

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Less than 34 weeks gestation and less than 1500 g at birth * Greater than or equal to 36 weeks gestation and either with hypoxic respiratory failure or with mild respiratory distress never requiring assisted ventilation Exclusion Criteria: * Life threatening anomalies of any organ system (e.g., cardiac, thoracic, lethal, or non-lethal chromosomal abnormalities)

Locations (2)

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, United States

Truman Medical Center

Kansas City, Missouri, United States

Data from ClinicalTrials.gov

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