Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

University of California, Irvine

Overview

The purpose of this study is to determine whether propranolol is better than oxytocin for the treatment of labor abnormalities. The endpoint is the rate of vaginal delivery experienced by women receiving prolonged oxytocin versus propranolol.

This trial was designed to test if propranolo can reduce the c section rate for dysfuctional labor. Due to stringent inclution and exclusion criteria and low enrollment the study was closed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Conditions

Dysfunctional Labor

Interventions

PropranololDRUG

IV Propranolol 1mg/min for a total of 2 minutes. Total dose 2mg

IV PlaceboOTHER

IV Saline Solution

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Must be term pregnancy (\> 37 weeks) * Vertex presentation * Active labor (4-5 centimeters dilated) Exclusion Criteria: * Heart disease * Diabetes * Currently taking propranolol * Contraindications to labor or vaginal delivery * Multiple gestations * Preterm * Chorioamnionitis

Locations (1)

Long Beach Memorial Medical Center

Long Beach, California, United States

Data from ClinicalTrials.gov

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