Sexual Functioning Study With Antidepressants

Inclusion criteria: * Primary diagnosis of Major Depressive Disorder (MDD) * must have met DSM-IV criteria for current major depressive episode for at least 8 weeks but no long than 2 years. * HAM-D17 total score of \>17 at screening and baseline. * Severity of illness score of \>4 at screening and baseline. * Willing to discuss sexual functioning with investigator or designee. * Sexual activity that leads to orgasm at least every 2 weeks. Exclusion Criteria: * Past or current DSM-IV diagnosis of Bipolar Disorder I or II, schizophrenia or another psychotic disorder(s). * Primary DSM-IV diagnosis or received treatment for Panic Disorder, Obsessive Compulsive Disorder or Post Stress Disorder within previous 12 months. * Poses a homicidal or serious suicidal risk, have made an attempt within months prior to screening or who has ever been homicidal. * Myocardial infarction with 1 year of screening. * Taken ibupropion hydrochloride or venlafaxine in the last 6 months. * Positive urine test for illicit drug use or alcohol or substance abuse within the past 12 months. * Psychotherapy within 3 months. * Pregnant. * Electroconvulsive therapy or transcranial magnetic stimulation within 6 months prior of screening. * ECG or clinical evidence of atrial or ventricular hypertrophy.