Phase 1 Trial of a Malaria Vaccine in Young Kenyan Children

Inclusion Criteria: * A healthy male or female child, 12 to 47 months of age at the time of screening. * Written informed consent obtained from at least one parent before study start. * Available to participate for the duration of the study (12 months). Exclusion Criteria: * Acute disease at the time of entry into the study * Axillary temperature of 37.5 degrees C * Respiratory rate 50 * Serum ALT 45 IU/l (i.e., \> 1.5 X ULN) * Decreased renal function: serum creatinine levels \> 92.2 mM/l (\> 1.1 mg/dl). * Significant anemia (Hgb \<8 gm/dL). * Thrombocytopenia (Platelets \< 100,000 per mm3) * Impaired immunity: (Absolute lymphocyte count \[ALC\] for 1 year olds \< 4.0 x 103/mm3; for 2 year olds \< 3.0 x 103/mm3; for 3 year olds \< 2.0 103/mm3. * History of homozygous sickle cell disease (SS). * Malnutrition (Z score; Malnutrition = Weight for height \< - 3 z scores) * Blood transfusion or use of blood-based product in previous 6 months. * Prior receipt of a rabies vaccine or an investigational malaria vaccine. * Use of any investigational drug or vaccine other than the study vaccine within 30 days preceding the first dose of study vaccine, or planned use up to 30 days after the third dose. * Administration of chronic (defined as more than 14 days) immunosuppressants or other immune-modifying drugs within six months of vaccination. (For cortico-steroids, this will mean prednisone, or equivalent, greater than or equal to 0.5 mg/kg/day. Inhaled and topical steroids are allowed). * Administration or anticipated administration of a vaccine not foreseen by the study protocol within 30 days of the first dose of vaccine(s) with the exception of tetanus toxoid. * Previous vaccination with a vaccine containing MPL or QS21 (e.g., RTS,S). * Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection. (No HIV testing will be undertaken as part of this study.) * History of allergic reactions or anaphylaxis to immunizations or to any vaccine components. * History of surgical splenectomy. * Administration of immunoglobulins or any blood products within the 3 months preceding the first dose of study vaccine or planned administration during the study period. * Simultaneous participation in any other clinical trial. * Acute or chronic cardiovascular, pulmonary, hepatic or renal condition, which in the opinion of the PI may increase the risk to the subject from participating in the study. * Any other condition or circumstance that in the opinion of the investigator may pose a threat to the subject.