Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors

Aarhus University Hospital Skejby50 enrolled

Overview

Hypothesis: Metformin treatment normalises hormone values and metabolic parameters in women with PCOS. Ovulation is restored and bleeding periods become regular. Fifty women with PCOS (Rotterdam criteria) are randomised to either placebo or metformin for 6 months. After a wash-out period of 3 months, the opposite treatment is given for another 6 months. Measurements are performed before ech treatment period, every second month during treatment and after completing treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Polycystic Ovary Syndrome

Interventions

MetforminDRUG

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of PCOS * Age 20 - 45 Exclusion Criteria:Diabetes * Diabetes * Hormonal treatment * Pregnancy, lactation * Periclimacteric

Data from ClinicalTrials.gov

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