Pilot Prospective Study: Long-term Health of Living Kidney Donors

Inclusion Criteria: 1. Age greater than 18 years old 2. A predicted Cockcroft-Gault creatinine clearance \> 80 mL/min 3. Average sBP \< 140 and dBP \< 90 based on 3 readings 4. A spot urine protein to creatinine ratio \< 15 mg/mmol Exclusion Criteria: 1. A medical condition (such as cardiovascular disease, pulmonary disease, active cancer) or psychological condition (such as major affective disorder, personality disorder, a history of chemical dependence) which the local transplant centre deems unfit for donation. Blood group and immunological incompatibility (such as positive cross-match, poor HLA matches) are not reasons for exclusion 2. Evidence of a financial incentive for donation 3. A contraindication to general anaesthesia or surgery 4. A past medical history of hypertension 5. Use of antihypertensive class medications for any reason.(ACE-Is, ARBs, diuretics, beta-blockers, calcium channel blockers) 6. A past history of permanent proteinuria 7. The eligible non-donor is planning to donate their kidney within the next year 8. Unable to give informed consent 9. Unwilling to participate in the follow-up assessments at one, two, three, four and five years, or unwilling or unable to conduct home blood pressure or laboratory measurements 10. The living donor or eligible non-donor is currently pregnant 11. Despite being planned the donor nephrectomy does not take place 12. Enrolled in another clinical study which interferes with the conduct or outcomes of this study