Computer-Based Therapy for Mild Cognitive Impairment

Phase 1CompletedNCT00319943

Posit Science Corporation48 enrolled

Overview

The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).

The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Mild Cognitive Impairment

Interventions

Computer-based training for Mild Cognitive Impairment (MCI)PROCEDURE

Eligibility

Sex: ALLMin age: 65 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1)65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function. 3)Fluency in English 4)Willing to meet the time commitment of the study \- Exclusion Criteria: 1. Clinically significant cerebrovascular disease 2. Individuals scheduled to begin acetylcholinesterase inhibitor (AChEI) therapy -

Locations (1)

University of California, San Francisco

San Francisco, California, United States

Outcomes

Primary Outcomes

The study investigates changes in a neuropsychological assessment battery pre-randomization

and upon the completion of training.

Secondary Outcomes

Early evaluations will be conducted from brain imaging; specifically, date

obtained via positron emission tomography (PET), magnetoencephalography (MEG),

electroencephalography (EEG), and functional magnetic resonance imaging (fMRI)

studies.

Data from ClinicalTrials.gov

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