Effect of Pyridorin in Patients With Diabetic Nephropathy

Inclusion Criteria: * Males and Females (non-pregnant and non-lactating) between 18 and 70 years of age with type 1 or type 2 diabetes * Sitting blood pressure of \<=170/100 mm Hg at weeks -2 and -1 * Hemoglobin A1C \<=12% at week -2 * Patients with diagnosis of diabetic nephropathy as defined by 1. Serum Creatinine \<=2.0 mg/dL at weeks -2 and -1 2. Urinary albumin excretion \>=300 mg/24 hours at week -2 3. Diagnosis of diabetic retinopathy * Creatinine clearance \>=40 mL/min at weeks -2 and -1 * Voluntary written consent to participate in this study Exclusion Criteria: * History of allergic or adverse response to any B vitamin * History of major cardiovascular or cerebrovascular events * History of cancer except adequately treated basal or squamous cell carcinoma of the skin * History of diabetic ketoacidosis