Serotonin Transporter Concentrations in Women With a History of Anorexia Nervosa

Inclusion Criteria: * History of anorexia nervosa * BMI has been greater than 18.5 kg/m² for at least 9 months * Agrees to use an effective method of contraception * Off all psychotropic and other types of medications likely to impact the serotonin system for at least 21 days Exclusion Criteria: * Use of any psychotropic medication or other types of medications that are likely to affect the serotonin system within 21 days of study entry * Current DSM-IV Axis-I diagnosis of any illness other than an eating disorder * Current AN or history of AN within 9 months prior to study entry * Presence of any psychiatric symptom that would make participation unsafe * Significant active physical illnesses, particularly those that may affect the brain or serotonergic system, including the following: blood dyscrasias lymphomas; hypersplenism; endocrinopathies; renal failure or chronic obstructive lung disease; autonomic neuropathies; low hemoglobin; anemia; peripheral vascular disease; and malignancy * Currently receiving effective medication treatment for an eating disorder * History of Raynaud's phenomena and/or acrocyanosis * Significant regular tobacco use (defined as more than 1 pack per week) * Lacks capacity to consent * Pregnant * Breastfeeding * Any metal implants, pacemaker, metal prostheses, orthodontic appliances, or the presence of shrapnel * Significant history of claustrophobia that would complicate the completion of MRI * Current or past radiation exposure in the workplace or as part of a research protocol in the previous year * Badged for radiation Inclusion for Healthy Controls: * Female age 18-45 * BMI \>18.5 kg/m * Drug and medication free * Willingness to engage in effective birth controls Exclusion for Healthy Controls * History of any DSM-IV Axis - I diagnosis * History of Axis II disorder that would be accompanied by impulse control problems or significant suicidal behavior * Significant active physical illness * Lacks capacity to consent * Pregnancy, currently lactating * Metal implants, pacemaker or metal prostheses or orthodontic appliances or shrapnel * Current, past radiation exposure in the workplace or as part of a research protocol in the previous year or badged for radiation