LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin

Inclusion Criteria: * Age 18 to 80 * Anterior myocardial infarction with: 1. Pathological Q-waves in at least 3 contiguous anterior precordial leads, assumed to be new 2. CK peak\>5 times the upper limit of normal with positive MB bands * Ejection fraction \<=40% or anterior dyskinesis or documented LV Thrombus * MI onset \< 7 days from randomization Exclusion Criteria: * Inability to give written informed consent * Medical conditions that would prohibit discharge within 48 hours with the exception of need for anticoagulation * Cardiogenic shock, rest angina unresponsive to medical therapy or serious ventricular arrhythmia in the 24 hours prior to randomization * Patients scheduled for surgical procedure in the next 4 months that would prevent use of enoxaparin or warfarin * Anemia: Baseline Hgb\<=9 gm for women, \<=10 gm for men or platelet count\<100,000 * Renal insufficiency (creatinine \>2.0 mg/dl) * Serious liver disease as reflected by INR\>1.3 * Stroke within past 6 months or a prior documented intracranial or subarachnoid hemorrhage * Active bleeding or major surgery within 2 weeks prohibiting the use of anticoagulants * Acute pericarditis * Women of childbearing potential unless pregnancy test negative * Cardiac or non-cardiac condition with expected survival\< 6 months * Severe peripheral vascular disease * Patients who undergo cardiac surgery, including CABG, as a result of their index myocardial infarction * Allergy to aspirin, heparin or warfarin, pork or pork products * History of recurrent thromboembolic disease or a history of Protein C, Protein S, antithrombin III deficiency or known bleeding disorder. * Current use of warfarin or need for chronic anticoagulation * Current participation in other trials using investigational drugs or devices * Prior enrollment in this trial