The Beta Cell Responsiveness to Glucose-dependent Insulinotropic Polypeptide (GIP) With and Without Sulfonylurea in Patients With Type 2 Diabetes

University Hospital, Gentofte, Copenhagen12 enrolled

Overview

The investigators hypothesize that the impaired insulinotropic effect of the incretin hormone GIP may be due to inadequate sensitization and ATP induced closure of beta cell K-ATP channels. By closing the channels through the use of sulfonylurea (SU) we hope to restore the insulinotropic effect of GIP.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Diabetes Mellitus, Type 2

Interventions

SulfonylureaDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Type 2 diabetes mellitus diagnosed according to WHO criteria * Diet and/or metformin treatment * HbA1c \> 7,0% for metformin treated patients * HbA1c \> 7,5% for diet treated patients * Age: 18 years or older * 25 \> BMI \> 40 kg/m2 * Signed informed consent * Sufficient birth control in case of child bearing capacity Exclusion Criteria: * Proliferative retinopathy * Diabetic nephropathy with s-creatinine \> 130 microM and/or macroalbuminuria * Liver disease (ALAT \> 2 x normal value) * CAD (NYHA group III or IV) * Positive screening for islet-cell and/or GAD-65 autoantibodies * Type 1 diabetes i first degree relatives * Gastrointestinal surgery with intestinal resection * Anemia * Pregnancy and/or breastfeeding

Locations (1)

Department of Internal Medicine, Gentofte University Hospital

Hellerup, Copenhagen, Denmark

Outcomes

Primary Outcomes

Insulin Secretion

area under the curve AUC and insulin secretion rate

Time frame: 0 - 90 minutes

Data from ClinicalTrials.gov

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