A Study Of GW679769 Compared To Placebo In Women With Overactive Bladder

Inclusion Criteria: * Female subjects with overactive bladder with symptoms of urgency with urge incontinence and frequency which may be associated with nocturia but without bladder pain. * Must not be pregnant. * Must not be of childbearing potential or is willing to use specific barrier methods outlined in the protocol. * Body weight in the range of = 45 kg and \<100 kg. Exclusion Criteria: * Stage III/IV pelvic organ prolapse with or without cystocele. * History of interstitial cystitis or bladder related pain. * Subjects with stress incontinence or mixed incontinence where stress incontinence is the predominant component based on prior history. * History of pelvic prolapse repair (cystocele or rectocele) or urethral diverticulectomy within six months of screening. * Subjects with urinary incontinence due to causes other then detrusor over activity (e.g., overflow incontinence). * Nocturnal enuresis only. * Urinary retention, or other evidence of poor detrusor function. * History of prior anti-incontinence surgery. * History of radiation cystitis or a history of pelvic irradiation. * Electrostimulation, biofeedback, or bladder training therapy (behavioral therapy) during the previous month prior to screening, or the intention to initiate such therapies during the study. Pessaries and implants are also excluded. * Participated in any clinical trial of an investigation drug that may affect urinary function within 3 months of enrollment into the study. * Received any investigational product within 30 days of enrollment into the study.