Drug-drug Interaction Study of Aripiprazole and Lamotrigine in Patients With Bipolar Type I Disorder

Inclusion Criteria: * Body mass index (BMI) of 18 to 40 kg/m2 * Subjects with bipolar I disorder who are clinically stable on a stable dose of at least 100 mg lamotrigine for at least 4 weeks prior to study entry * Men and women, ages 18 to 65 Exclusion Criteria: * Women who are pregnant or breastfeeding * Patients with any significant acute or chronic medical illness, other than bipolar I disorder * Subjects with active psychotic symptoms * History of head trauma within the past 2 years * History of akathisia requiring treatment * History of tardive dyskinesia or abnormal involuntary movements * Subjects with a predisposition to orthostatic hypotension * Positive urine screen for drugs of abuse * Use of narcotic-containing agents, amphetamines, or hormonal contraceptives within 4 weeks of study start