Reduced Anti-Platelet Therapy With Pimecrolimus Drug Eluting Stent (RAPID)

Inclusion Criteria: General Inclusion Criteria 1. Eligible for percutaneous coronary intervention (PCI). 2. Documented stable or unstable angina pectoris 3. Left ventricular ejection fraction (LVEF) ≥25% 4. Acceptable candidate for coronary artery bypass graft surgery (CABG). 5. Target Lesion \< 25 mm in length with RVD of 2.5 to 3.5 mm with visually estimated stenosis of \>= 50 and \< 100 %. Exclusion Criteria: General Exclusion Criteria 1. Known sensitivity to pimecrolimus, the polymer (PLGA) or cobalt chromium. 2. Planned treatment with any other PCI device in the target vessel(s). 3. MI within 72 hours prior to the index procedure 4. The patient is in cardiogenic shock. 5. Cerebrovascular Accident (CVA) within the past 6 months. 6. Acute or chronic renal dysfunction 7. Contraindication to ASA or to clopidogrel. 8. Thrombocytopenia 9. Active gastrointestinal (GI) bleeding within the past 3 months. 10. Any prior true anaphylactiod reaction to contrast agents 11. Patient is currently taking chronic systemic steroid therapy or systemic immunosuppressant therapy or topical pimecrolimus. 12. Female of childbearing potential. 13. Life expectancy of less than 24 months due to other medical conditions. 14. Co-morbid condition(s) 15. Currently participating in another investigational drug or device study