A Study of the Effect on Oro-dental Complications of Intensity Modulated Radiotherapy (IMRT) Versus Conventional Radiotherapy in Patients With Cancer of the Head or Neck

University Hospital, Ghent43 enrolled

Overview

Study to investigate the effect of two types of radiotherapy on saliva: IMRT versus conventional radiotherapy. In each group, one part will receive normal dental preventive treatment. The other part will use products for treatment of dry mouth (Biotene gamma). Both anorganic and organic components of the saliva will be studied at different time points, combined with bacterial swabs.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cancer: Head or Neck

Interventions

IMRT versus conventional radiotherapyPROCEDURE

Comparing MRT versus conventional radiotherapy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years old * Cancer of head or neck Exclusion Criteria: \-

Locations (1)

University Hospital Ghent

Ghent, Belgium

Outcomes

Primary Outcomes

Volume of saliva

Time frame: Before, during (week 4) and after radiation (week 2, 3, 6 and 12)

Quality of saliva

Time frame: Before, during (week 4) and after radiation (week 2, 3, 6 and 12)

Oral flora

Time frame: Before, during (week 4) and after radiation (week 2, 3, 6 and 12)

Data from ClinicalTrials.gov

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