Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone

Fredericia Hosptial10 enrolled

Overview

Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management of kidney stone by topical administration of drugs? In order to secure fewer complications in ureteroscopic operations the pharmacological agent isoproterenol is tested on pigs and human to determine its potential of lowering intrarenal pressure.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Kidney Stone Ureteroscopy

Interventions

IsoproterenolDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Indication for RIRS procedure * Age \> 18 years * Normotensive * Capable of understanding information given Exclusion Criteria: * Previous myocardiac infarct * Daily use of alpha- og beta- blocking medicine og calcium antagonists * Use of NSAID the last 2 days * Stone in the ureter * Declared * Known malignant disease in urinary tract * Bladder disease * Nephrostomies inserted * JJ-catheters inserted * Prisoners * Pregnant * Nursing mothers

Locations (1)

Dpt. of Urology

Fredericia, Vejle Council, Denmark

Outcomes

Primary Outcomes

Renal pelvic pressure

Secondary Outcomes

Blood pressure

Pulse

Data from ClinicalTrials.gov

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