Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester

University of Florida30 enrolled

Overview

The purpose of this study is to compare two methods of pregnancy termination on the time to delivery in the second trimester.

Medical termination in the second trimester is performed for many indications. Successful termination is dependant on ripening of the cervix prior to labor induction. Multiple methods of cervical ripening and labor induction have been used for pregnancy termination in the second trimester. These two methods have different mechanisms of action. This study seeks to evaluate the effectiveness of these two methods.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Pregnancy Trimester, Second Induced Abortion

Interventions

Foley bulbDEVICE

misoprostolDRUG

Eligibility

Sex: FEMALEMin age: 14 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * indication for pregnancy termination, gestational age from 13-27 weeks Exclusion Criteria: * multiple gestation, previous uterine surgery, rupture of membranes, latex allergy

Locations (1)

Shands Hospital at the University of Florida

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Time to vaginal delivery

Secondary Outcomes

Rate of chorioamnionitis

Rate of maternal fever

Rate of postpartum hemorrhage

Data from ClinicalTrials.gov

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